D. A. Price

Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq

This paper introduces TCR-Track, a method to map and track helper T cell subsets in scRNA-Seq data, revealing their clonal relationships and functional programs over time.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

This study identifies Lrp1 as a host factor required for Oropouche orthobunyavirus infection and suggests a broader role for Lrp1 in bunyavirus entry.

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

The Polarization Dependence of 2D IR Cross-Peaks Distinguishes Parallel-Stranded and Antiparallel-Stranded DNA G-quadruplexes

This study uses 2D IR spectroscopy to distinguish between parallel- and antiparallel-stranded G-quadruplexes by analyzing polarization-dependent cross-peaks.

Membrane-Dependent Amyloid Aggregation of Human BAX α9 (173-192)

This study shows that the BAX α9 peptide forms amyloid aggregates in solution and on anionic vesicles, challenging prior models of its pore-forming activity.

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

The paper maps SARS-CoV-2-specific T cell responses in individuals with asymptomatic/mild COVID-19 and finds robust memory T cell responses similar to vaccines, detectable even in antibody-seronegative individuals.

Identification of a lymphocyte minor histocompatibility antigen in Mauritian cynomolgus macaques

The paper identifies a minor histocompatibility antigen in Mauritian cynomolgus macaques using alloimmunization, exome sequencing, and bioinformatics, showing its potential as a target for HIV immunotherapies.

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.