Author

P. M. Loria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

S. Han· 2 shared A. M. Mathiowetz· 1 shared A. P. Berg· 1 shared A. R. Saxena· 1 shared A. S. Kalgutkar· 1 shared C. Buckeridge· 1 shared C. Limberakis· 1 shared D. A. Griffith· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

S. Han

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2 papers

Recent·Most cited

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

T. J. McCorvie, P. M. Loria, M. Tu, S. Han, L. Shrestha, D. S. Froese, I. M. Ferreira, A. P. Berg, W. W. Yue

This study presents cryo-EM structures of phosphorylated human GYS1 complexed with GYG1, revealing how phosphorylation and glucose-6-phosphate regulate glycogen synthase activity.

bioRxiv · Nov 12, 2021Biochemistry

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

D. A. Griffith, D. J. Edmonds, J.-P. Fortin, A. S. Kalgutkar, J. B. Kuzmiski, P. M. Loria, A. R. Saxena, S. W. Bagley, C. Buckeridge, J. M. Curto, D. R. Derksen, J. M. Dias, M. C. Griffor, S. Han, V. M. Jackson, , D. A. Tess

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

bioRxiv · Sep 29, 2020Pharmacology & Toxicology