Author

D. A. Griffith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Gouridis· 2 shared N. Zijlstra· 2 shared T. Cordes· 2 shared A. Doemling· 1 shared A. Economou· 1 shared A. Guskov· 1 shared A. Jager· 1 shared A. M. Mathiowetz· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

G. Gouridis

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Author profile →

3 papers

Recent·Most cited

Structural and biophysical characterization of the tandem substrate-binding domains of the ABC importer GlnPQ

E. Ploetz, G. Schuurman-Wolters, N. Zijlstra, A. Jager, D. A. Griffith, A. Guskov, G. Gouridis, B. Poolman, T. Cordes

This paper characterizes the structural and biophysical properties of the tandem substrate-binding domains of the ABC importer GlnPQ using crystal structures, calorimetry, and smFRET.

bioRxiv · Dec 19, 2020Biophysics

Evolution of structural dynamics in bilobed proteins

G. Gouridis, Y. Muthahari, M. de Boer, K. Tassis, A. Tsirigotaki, N. Zijlstra, N. Eleftheriadis, R. Xu, M. Zacharias, D. A. Griffith, Y. Sugijo, A. Doemling, S. Karamanou, A. Economou, T. Cordes

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

bioRxiv · Oct 19, 2020 · PreprintBiophysics

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

D. A. Griffith, D. J. Edmonds, J.-P. Fortin, A. S. Kalgutkar, J. B. Kuzmiski, P. M. Loria, A. R. Saxena, S. W. Bagley, C. Buckeridge, J. M. Curto, D. R. Derksen, J. M. Dias, M. C. Griffor, S. Han, V. M. Jackson, , D. A. Tess

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

bioRxiv · Sep 29, 2020Pharmacology & Toxicology