S. Gurung

Timp2 loss-of-function mutation and TIMP2 treatment in murine model of NSCLC: modulation of immunosuppression and oncogenic signaling

TIMP2 treatment compensates for TIMP2 mutation to reveal immunomodulatory and oncogene regulation that inhibits tumor growth and metastatic niche formation.

The incidence of movement disorders increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria.

This study investigates movement disorders in argininosuccinic aciduria (ASA), finding they increase with age and show specific neuroimaging abnormalities not seen in mouse models.

Ex vivo primary liver sections recapitulate disease phenotype and therapeutic rescue for liver monogenic diseases

This study uses precision-cut liver sections from mice to model monogenic liver diseases and test gene therapy efficacy.

EARLY AND MID-GESTATION ZIKA VIRUS (ZIKV) INFECTION IN THE OLIVE BABOON (PAPIO ANUBIS) LEADS TO FETAL CNS PATHOLOGY BY TERM GESTATION

This study examines ZIKV infection in Olive baboons during early and mid-gestation, finding fetal CNS pathology by term gestation despite resolved viremia.

Whole Organism Profiling of the Timp Gene Family

The paper analyzes Timp gene expression across healthy tissues using single-cell RNA sequencing to identify cell-type-specific patterns and expand on these findings with RNA in-situ hybridization.

Female immunity protects from cutaneous squamous cell carcinoma

The paper shows women are more protected from aggressive cutaneous squamous cell carcinoma due to stronger immune activation compared to men.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

Impact of sustained TGFβ receptor inhibition on chromatin accessibility and gene expression in cultured human endometrial MSC

This study examines how sustained TGFβ receptor inhibition affects gene expression and chromatin accessibility in human endometrial MSC, identifying key gene networks and chromatin changes that maintain an undifferentiated state.

MATERNAL ZIKA VIRUS (ZIKV) INFECTION FOLLOWING VAGINAL INOCULATION WITH ZIKV-INFECTED SEMEN IN THE TIMED-PREGNANT OLIVE BABOON

This study infects pregnant olive baboons with ZIKV-infected semen via vaginal deposition, showing maternal infection and vertical transmission, with differences in tissue dissemination between ZIKV isolates.

Preparation and characterization of phospholipid stabilized nanoemulsions in small-scale

This paper develops a small-scale method to prepare phospholipid-stabilized nanoemulsions with minimal liposome formation, achieving stable nanoemulsions with particle size <200 nm and PDI <0.1.