E. Kay

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Dual control of host actin polymerization by a Legionella effector pair

This study identifies LegK2 and VipA as antagonistic effectors in Legionella pneumophila that regulate actin polymerization and bacterial virulence through distinct substrates.

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

Development of a novel glycoengineering platform for the rapid production of conjugate vaccines.

This paper develops a novel glycoengineering platform, MAGIC, which increases glycoconjugate yield and enables vaccine development in genetically intractable bacteria.

Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling

This study assesses the feasibility of genome-wide DNA methylation profiling from oak heartwood, finding that older samples are challenging due to DNA degradation and phenolic compounds.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

Access to unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis

This study introduces TRIAD, a transposon mutagenesis method to generate InDels for directed enzyme evolution, showing distinct functional outcomes compared to point mutagenesis.