FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors
J. Pagan, G. Nguyen-Dien, K. Kozul, Y. Cui, B. Townsend, S. S. Ooi, M. Pagano, M. Lazarou, R. Taylor, B. M. Collins, R. G. Parton, P. Kulkarni, N. Carrodus, S. Zuryn, S. Millard, , M. Jones
This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.
bioRxiv · Oct 12, 2022Cell Biology