B. M. Collins

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

Mechanism and regulation of cargo entry into the Commander recycling pathway

The paper identifies the mechanism by which SNX17 cargo is selected for entry into the Commander recycling pathway through direct binding to the Retriever sub-complex.

Polarity-dependent expression and localization of secretory glucoamylase mRNA in filamentous fungal cells

This study visualizes and analyzes the spatial and temporal dynamics of glaA mRNA in Aspergillus oryzae, revealing its localization near hyphal tips and septa and its dependence on microtubule motors.

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

This study defines how FAM21 couples SNX27-Retromer to the WASH complex through motif-based interactions essential for endosomal recycling.

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resistance

The paper shows that caveola disassembly under mechanical stress reinforces the actin cortex at adherens junctions, enhancing epithelial resistance to tensile stress.

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.

This study identifies the molecular mechanism by which SNX27-Retromer interacts with ESCPE-1 to facilitate endosomal cargo recycling, revealing a conserved surface interaction and evolutionary pathway.

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.