Author

A. Marzook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Tomas· 2 shared B. Jones· 2 shared D. Hodson· 2 shared J. Broichhagen· 2 shared M. Lucey· 2 shared S. R. Bloom· 2 shared Y. Wang· 2 shared A. Oishi· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Tomas

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2 papers

Recent·Most cited

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

A. Marzook, S. Chen, P. Pickford, M. Lucey, Y. Wang, I. R. Correa, J. Broichhagen, D. Hodson, V. Salem, G. A. Rutter, T. M. Tan, S. R. Bloom, A. Tomas, B. Jones

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

bioRxiv · Apr 1, 2021Pharmacology & Toxicology

Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

M. Lucey, T. Ashik, A. Marzook, Y. Wang, J. Goulding, A. Oishi, J. Broichhagen, D. Hodson, J. Minnion, Y. Elani, R. Jockers, S. J. Briddon, S. R. Bloom, A. Tomas, B. Jones

This study compares exendin-4 and its acylated variant exendin-4-C16, showing acylation affects GLP-1R signaling bias, trafficking, and pharmacokinetics.

bioRxiv · Apr 1, 2021Pharmacology & Toxicology