Author

A. Nadal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. Marroqui· 5 shared R. S. Dos Santos· 5 shared I. Babiloni-Chust· 3 shared R. M. Medina-Gali· 3 shared A. A. Perez-Serna· 2 shared J. A. Encinar· 2 shared J. Martinez-Pinna· 2 shared J.-A. Gustafsson· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersPharmacology & Toxicology

L. Marroqui

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human beta cells against proinflammatory insults

R. S. Dos Santos, D. Guzman-Llorens, A. A. Perez-Serna, A. Nadal, L. Marroqui

This study shows deucravacitinib protects human beta cells from proinflammatory cytokines without affecting their survival or function.

bioRxiv · Dec 27, 2022 · PreprintCell Biology

Screening of metabolism-disrupting chemicals on pancreatic alpha-cells using in vitro methods

R. S. Dos Santos, I. Babiloni-Chust, L. Marroqui, A. Nadal

This study evaluates the effects of six metabolism-disrupting chemicals on pancreatic alpha-cell viability and function using in vitro methods.

bioRxiv · Nov 7, 2022Pharmacology & Toxicology

Development of in vitro test methods in a model of human pancreatic β-cells to identify metabolism disrupting chemicals with diabetogenic activity

R. S. Dos Santos, R. M. Medina-Gali, I. Babiloni-Chust, L. Marroqui, A. Nadal

The paper tests six chemicals on human and rodent β-cells to identify metabolism-disrupting chemicals with diabetogenic activity, finding PFOA reduces glucose-stimulated insulin secretion.

bioRxiv · Mar 22, 2022 · PreprintPharmacology & Toxicology

G protein-coupled estrogen receptor activation by Bisphenol-A disrupts protection from apoptosis conferred by estrogen receptors ERα and ERβ in pancreatic beta cells

I. Babiloni-Chust, R. S. Dos Santos, R. M. Medina-Gali, A. A. Perez-Serna, J. A. Encinar, J. Martinez-Pinna, J.-A. Gustafsson, L. Marroqui, A. Nadal

This paper shows that BPA induces apoptosis in pancreatic beta cells by reducing ERβ heterodimers, while GPER activation by G1 has a similar effect, highlighting a novel mechanism of endocrine disruption.

bioRxiv · Jan 31, 2022Physiology

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

L. Marroqui, J. Martinez-Pinna, M. Castellano-Munoz, R. S. Dos Santos, R. M. Medina-Gali, S. Soriano, I. Quesada, J.-A. Gustafsson, J. A. Encinar, A. Nadal

This study shows BPS and BPF affect mouse β-cell ion channels and insulin release via ERβ pathways, with effects absent in ERβ knockout mice.

bioRxiv · Sep 30, 2020Pharmacology & Toxicology