A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia
L. Menin, J. Weber, S. Villa, E. Martini, E. Maspero, V. Cancila, P. Maiuri, A. Palamidessi, E. Frittoli, F. Bianchi, C. Tripodo, K. Walters, F. Giavazzi, G. Scita, S. Polo
The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.
bioRxiv · Jan 23, 2023Cell Biology