Author

S. Sigismund

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Barbieri· 2 shared G. Scita· 2 shared P. P. Di Fiore· 2 shared A. Bresci· 1 shared A. Palamidessi· 1 shared A. Raimondi· 1 shared C. Malinverno· 1 shared C. Tacchetti· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

E. Barbieri

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2 papers

Recent·Most cited

A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism

D. Salvi Mesa, E. Barbieri, A. Raimondi, S. Freddi, G. Miloro, G. Jendrisek, G. Caldieri, M. Quarto, I. Schiano Lomoriello, M. G. Malabarba, A. Bresci, F. Manetti, F. Vernuccio, H. Abdo, G. Scita, , S. Sigismund

The paper shows that EGFR signaling via non-clathrin endocytosis requires a tripartite organelle platform linking Ca2+ oscillations to mitochondrial metabolism and ATP production for actin remodeling and collective motility.

bioRxiv · Jan 15, 2024Cell Biology

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

A. Palamidessi, C. Malinverno, E. FRITTOLI, S. Corallino, E. Barbieri, S. Sigismund, P. P. Di Fiore, G. V. Beznoussenko, E. Martini, M. Garre, D. Parazzoli, I. Ferrara, C. Tripodo, F. Giavazzi, R. Cerbino, G. Scita

This study identifies the RAB5A-driven endo-ERK1/2 pathway as a mechanism for unjamming in epithelial tissues and carcinoma, enabling collective motility and invasion.

bioRxiv · Sep 17, 2018Cancer Biology