G. Scita

A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism

The paper shows that EGFR signaling via non-clathrin endocytosis requires a tripartite organelle platform linking Ca2+ oscillations to mitochondrial metabolism and ATP production for actin remodeling and collective motility.

A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.

Ena/VASP clustering at microspike tips involves Lamellipodin but not I-BAR proteins, and absolutely requires unconventional Myosin-X

This study identifies unconventional Myosin-X as essential for Ena/VASP clustering and microspike formation, while showing Lamellipodin is involved but inverse BAR-domain proteins are not.

A mechanosensing mechanism mediated by IRSp53 controls plasma membrane shape homeostasis at the nanoscale

The paper identifies a mechanosensing mechanism involving IRSp53 that detects and restores plasma membrane nano-scale deformations through actin polymerization.

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

Compromised nuclear envelope integrity drives tumor cell invasion

The paper shows that mechanical nuclear envelope ruptures in cancer cells cause DNA damage and promote invasion through ATM activation and TREX1 depletion.

Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion

This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.

Mesoscale Dynamics of Spectrin and Acto-Myosin shape Membrane Territories during Mechanoresponse

The paper investigates how spectrin and acto-myosin cytoskeletons dynamically reorganize during mechanical challenges to support membrane territories.

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

This study identifies the RAB5A-driven endo-ERK1/2 pathway as a mechanism for unjamming in epithelial tissues and carcinoma, enabling collective motility and invasion.

Small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin independent endocytic vesicles

This study identifies the molecular machinery regulating clathrin and dynamin-independent endocytic vesicles, showing the sequential recruitment of ARF1/GBF1 and CDC42, and the roles of BAR domain proteins and actin polymerization.