P. Maiuri

Unraveling Glioblastoma Heterogeneity: Introducing SP2G Method for Identifying Invasive Sub-Populations

The paper introduces SP2G, a method to identify invasive sub-populations in glioblastoma cells by analyzing their motility on gridded micropatterns and linking it to molecular markers.

Pauperization of Emerin from nuclear envelope during chromatin bridge resolution drives prostate cancer cell migration and invasiveness

The paper shows that micronuclei formation during chromatin bridge resolution in prostate cancer cells leads to emerin pauperization from the nuclear envelope, enhancing cell migration and invasiveness.

SP2G: an imaging and analysis pipeline revealing the inter and intra-patient migratory diversity of glioblastoma

SP2G identifies invasive glioblastoma sub-populations through an in vivo mimicry platform and imaging analysis, revealing intra-patient heterogeneity in cell motility.

Vaccinia virus induces EMT-like transformation and RhoA-mediated mesenchymal migration

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.

Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.

The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

Adaptive mechanoproperties characterize glioblastoma fitness for invasion

The paper identifies FMN1 as a driver of glioblastoma invasiveness by linking it to increased cell stiffness, mechanical forces, and stochastic motility.

Mesoscale Dynamics of Spectrin and Acto-Myosin shape Membrane Territories during Mechanoresponse

The paper investigates how spectrin and acto-myosin cytoskeletons dynamically reorganize during mechanical challenges to support membrane territories.

Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency

The paper shows that myosin 1e and 1f are required for efficient phagocytosis by regulating adhesion turnover and actin dynamics during phagocytic cup closure.