Author

A. Pinedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Ha· 2 shared M. Delling· 2 shared C. H. Park· 1 shared C. J. Ye· 1 shared D. Raleigh· 1 shared E. Cao· 1 shared F. Ritu· 1 shared G. B. Loeb· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

K. Ha

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function

K. Ha, G. B. Loeb, M. Park, M. Gupta, Y. Akiyama, J. Argiris, A. Pinedo, C. H. Park, N. Brandes, F. Ritu, C. J. Ye, J. F. Reiter, M. Delling

This study classifies ADPKD-causing missense variants in polycystin-1 into two categories based on their effects on cell surface localization or ion channel function and suggests small-molecule therapies.

bioRxiv · Dec 4, 2023Cell Biology

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

K. Ha, N. Mundt, P. Bisignano, A. Pinedo, E. Cao, J. Reiter, D. Raleigh, M. Delling

This study identifies 7β,27-DHC as a critical oxysterol required for polycystin complex activation in cilia, revealing a lipid-mediated regulatory mechanism for ADPKD.

bioRxiv · Apr 13, 2022 · PreprintPhysiology