Y. Akiyama

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function

This study classifies ADPKD-causing missense variants in polycystin-1 into two categories based on their effects on cell surface localization or ion channel function and suggests small-molecule therapies.

Regulating Cell Orientation with a Femtosecond Laser-Induced Macro Stripe Design on Metallic Culture Surfaces

This paper introduces a metallic culture surface with a macro-stripe design created by femtosecond laser to guide cell orientation, showing myoblasts align towards mirrored regions due to enhanced adhesion and reduced wettability.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

Edge strand of Escherichia coli BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways

This study identifies how BepA interacts with immature LptD on the BAM complex to direct it to assembly or degradation pathways.

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.

Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

This study identifies interacting partners and mechanisms of VemP's translocation-coupled arrest-cancelation in Vibrio alginolyticus.

Reversible auto-inhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation

This study investigates how the α9/H246 loop in BepA regulates its protease activity, revealing a histidine switch mechanism that controls degradation of misassembled LptD.

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome

The paper develops RI-SEC-seq to analyze nonvesicular exRNAs, revealing extracellular ribosomes and tRNAs that resist degradation and act as damage-associated molecular patterns.