IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids
M. Larion, A. Lita, A. Pliss, A. Kuzmin, T. Yamasaki, L. Zhang, T. Dowdy, C. Burks, N. de Val, O. Celiku, V. Ruiz-Rodado, E.-R. Nicoli, M. Kruhlak, T. Andresson, S. Das, , P. N. Prasad
This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.
bioRxiv · Mar 20, 2020Cancer Biology