C. Herold-Mende

Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells

The paper investigates Calcitriol's effect on glioma stem-like cells, finding that some cell lines are sensitive while others are resistant, linked to Vitamin D3 receptor polymorphisms and proteomic changes.

EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma

This study identifies EMP3 as a regulator of EGFR/CDK2 signaling in glioblastoma by stabilizing EGFR and promoting its oncogenic activity.

Combining organotypic tissue culture with multi-color fluorescence light-sheet microscopy (OTCxLSFM) - a novel tool to study glioma invasion/migration

This study introduces OTCxLSFM, a method combining organotypic tissue culture and light-sheet microscopy to analyze glioma invasion, showing that arsenic trioxide and CD9 depletion block tumor infiltration.

Reprogramming M2-polarized patient-derived glioblastoma associated microglia/macrophages via CSF1R inhibition

This study shows that GW2580 reprograms M2-like glioblastoma-associated macrophages to M1-like cells, enhancing phagocytosis and T-cell killing, and reduces tumor cell proliferation in patient-derived organoids.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.