Author

N. de Val

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:chicken / avian· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. B. Ward· 2 shared M. Crispin· 2 shared A. D'addabbo· 1 shared A. Hajduczki· 1 shared A. Kuzmin· 1 shared A. Lita· 1 shared A. Maker· 1 shared A. Newman· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. B. Ward

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Author profile →

5 papers

Recent·Most cited

Structural bases for blockade and activation of BK channels by Ba2+ ions

S. Srivastava, P. Miranda Fernandez, N. de Val, T. Giraldez, J. Zhu, R. E. Cachau, M. Holmgren

The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.

bioRxiv · Jun 10, 2022Biophysics

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

M. Larion, A. Lita, A. Pliss, A. Kuzmin, T. Yamasaki, L. Zhang, T. Dowdy, C. Burks, N. de Val, O. Celiku, V. Ruiz-Rodado, E.-R. Nicoli, M. Kruhlak, T. Andresson, S. Das, , P. N. Prasad

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

bioRxiv · Mar 20, 2020Cancer Biology

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

M. G. Joyce, R. S. Sankhala, W.-H. Chen, M. Choe, H. Bai, A. Hajduczki, L. Yan, S. L. Sterling, C. Peterson, E. C. Green, C. Smith, N. de Val, M. Amare, P. Scott, E. D. Laing, , K. Modjarrad

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

bioRxiv · Mar 15, 2020 · PreprintImmunology

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

G. E. Seabright, C. A. Cottrell, M. J. van Gils, A. D'addabbo, D. J. Harvey, A.-J. Beherns, J. D. Allen, Y. Watanabe, A. Maker, S. Vasiljevic, N. de Val, R. W. Sanders, A. B. Ward, M. Crispin

The paper investigates how HIV-1 envelope glycan networks affect the formation and stability of broadly neutralizing antibody epitopes, showing their importance in immunogen design.

bioRxiv · Feb 21, 2020Immunology

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

R. Andrabi, J. Pallesen, J. Allen, G. Song, J. Zhang, N. de Val, G. Gegg, K. Porter, C.-Y. Su, M. Pauthner, A. Newman, H. Bouton-Vervelle, F. Garces, I. A. Wilson, M. Crispin, , D. R. Burton

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.

bioRxiv · Nov 1, 2018Immunology