Author

M. Kruhlak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. D. Tran· 1 shared A. Kuzmin· 1 shared A. Lita· 1 shared A. Nussenzweig· 1 shared A. Pliss· 1 shared A. V. Pankajam· 1 shared C. Burks· 1 shared C. Herold-Mende· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. D. Tran

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4 papers

Recent·Most cited

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

D. Zong, N. C. Koussa, J. A. Cornwell, A. V. Pankajam, M. Kruhlak, N. Wong, R. Chari, S. D. Cappell, A. Nussenzweig

This study maps the cellular response to WRN loss in MSI-H cancers, showing DNA damage accumulation and cell death, and suggests dual targeting of WRN and ATR as a therapeutic strategy.

bioRxiv · Jul 28, 2023Cancer Biology

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Y. Wang, O. Salvucci, H. Ohnuki, A. D. Tran, T. Ha, J.-X. Feng, M. DiPrima, H. Kwak, D. Wang, M. Kruhlak, G. Tosato

This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.

bioRxiv · Oct 6, 2020Cancer Biology

IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

M. Larion, A. Lita, A. Pliss, A. Kuzmin, T. Yamasaki, L. Zhang, T. Dowdy, C. Burks, N. de Val, O. Celiku, V. Ruiz-Rodado, E.-R. Nicoli, M. Kruhlak, T. Andresson, S. Das, , P. N. Prasad

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

bioRxiv · Mar 20, 2020Cancer Biology

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques

J. Petrovic, Y. Zhou, M. Fasolino, N. Goldman, G. Schwartz, M. Mumbach, S. Nguyen, K. Rome, Y. Sela, Z. Zapataro, S. Blacklow, M. Kruhlak, J. Aster, J. Shi, E. Joyce, , R. B. Faryabi

bioRxiv · Jan 22, 2019Cancer Biology