Author

A. R. Demonbreun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

E. M. McNally· 3 shared A. B. Willis· 2 shared A. D. Hoffmann· 1 shared A. H. Vo· 1 shared A. M. Long· 1 shared A. P. Amaral· 1 shared C. Mao· 1 shared C. Ostiguin· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

E. M. McNally

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Author profile →

4 papers

Recent·Most cited

The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix

J. G. O'Brien, A. B. Willis, A. M. Long, J. Kwon, G. Lee, F. Li, P. G. Page, A. H. Vo, M. Hadhazy, R. H. Crosbie, A. R. Demonbreun, E. M. McNally

This paper shows that the MRL mouse strain's extracellular matrix promotes muscle regeneration in muscular dystrophy by reducing fibrosis and enhancing myoblast growth.

bioRxiv · Jun 29, 2023Cell Biology

New semi-automated tool for the quantitation of MR imaging to estimate in vivo muscle disease severity in mice

E. A. Waters, C. R. Haney, L. A. Vaught, E. M. McNally, A. R. Demonbreun

This paper introduces a semi-automated MRI analysis tool to estimate muscle disease severity in mdx mice, showing it accurately segments muscle and reduces analysis time by 10-fold.

bioRxiv · May 23, 2023 · PreprintPathology

Recombinant annexin A6 promotes membrane repair in a stem cell derived-cardiomyocyte model of dystrophic cardiomyopathy

D. E. Fullenkamp, A. B. Willis, J. L. Curtin, A. P. Amaral, S. I. Harris, P. W. Burridge, A. R. Demonbreun, E. M. McNally

The paper demonstrates that recombinant annexin A6 reduces membrane damage in DMD iPSC-CMs under mechanical stress, showing potential therapeutic efficacy for DMD-related cardiomyopathy.

bioRxiv · Mar 9, 2022 · PreprintBioengineering

Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism

L. El-Shennawy, A. D. Hoffmann, N. K. Dashzeveg, P. J. Mehl, Z. Yu, V. L. Tokars, V. Nicolaescu, C. Ostiguin, Y. Jia, L. Li, K. Furlong, C. Mao, J. Wysocki, D. Batlle, T. J. Hope, , H. Liu

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

bioRxiv · Dec 3, 2020Immunology