Author

K. Furlong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:protein structure· 1

Frequent Co-Authors

V. Nicolaescu· 4 shared B. Manicassamy· 3 shared G. Randall· 3 shared S. Dvorkin· 3 shared A. C. Tremain· 2 shared A. Mansurov· 2 shared A. Solanki· 2 shared A. T. Alpar· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBioengineering

V. Nicolaescu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

L. R. Volpatti, R. P. Wallace, S. Cao, M. Raczy, R. Wang, L. T. Gray, A. T. Alpar, P. S. Briquez, N. Mitrousis, T. M. Marchell, M. S. Sasso, M. Nguyen, A. Mansurov, E. Budina, A. Solanki, , J. Hubbell

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

ACS Central Science · Jul 21, 2021Peer-reviewedBioengineering

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

L. T. Gray, M. M. Raczy, P. S. Briquez, T. M. Marchell, A. T. Alpar, R. P. Wallace, L. R. Volpatti, M. S. Sasso, S. Cao, M. Nguyen, A. Mansurov, E. Budina, E. A. Watkins, A. Solanki, N. Mitrousis, , J. A. Hubbell

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

bioRxiv · May 20, 2021Bioengineering

Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism

L. El-Shennawy, A. D. Hoffmann, N. K. Dashzeveg, P. J. Mehl, Z. Yu, V. L. Tokars, V. Nicolaescu, C. Ostiguin, Y. Jia, L. Li, K. Furlong, C. Mao, J. Wysocki, D. Batlle, T. J. Hope, , H. Liu

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

bioRxiv · Dec 3, 2020Immunology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection

M. Kandasamy, K. Furlong, J. T. Perez, S. Manicassamy, B. Manicassamy

This study shows that H5N1 influenza virus infection impairs cytotoxic T cell function and reduces tissue resident memory T cells, leading to delayed viral clearance and prolonged illness.

Journal of Virology · Apr 16, 2020Peer-reviewedMicrobiology