Author

D. R. Kovar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 8 Approach:experimental assay· 7 Assay:proteomics· 3 Approach:statistical model· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

C. Suarez· 4 shared M. L. Gardel· 4 shared G. A. Voth· 3 shared C. A. Anderson· 2 shared J. D. Winkelman· 2 shared P. M. McCall· 2 shared A. J. Harker· 1 shared A. R. Dinner· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCell Biology

C. Suarez

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Multi-monoubiquitination controls VASP-mediated actin dynamics

L. E. McCormick, C. Suarez, L. E. Herring, K. S. Cannon, D. R. Kovar, N. G. Brown, S. L. Gupton

This study shows that multi-monoubiquitination of VASP at specific lysine residues negatively regulates its actin-binding and bundling activities, affecting cell spreading morphology.

bioRxiv · Jul 16, 2023Cell Biology

Cracked actin filaments as mechanosensitive receptors

V. Zsolnay, M. L. Gardel, D. R. Kovar, G. A. Voth

This paper uses molecular dynamics simulations to show that mechanical strain on actin filaments creates a metastable cracked conformation, which serves as a binding site for LIM domain proteins.

bioRxiv · Jun 26, 2023Biophysics

Acetylation of fission yeast tropomyosin does not promote differential association with cognate formins

Q. Tang, L. Pollard, K. E. Homa, D. R. Kovar, K. M. Trybus

This study investigates whether acetylation of fission yeast tropomyosin affects its binding to formins, finding no preferential association with formin-mediated actin filaments.

bioRxiv · Nov 3, 2022Biochemistry

The actin assembly requirements of the formin Fus1 to build the fusion focus

I. Billault-Chaumartin, L. Michon, C. A. Anderson, S. E. Yde, C. Suarez, J. Iwaszkiewicz, V. Zoete, D. R. Kovar, S. G. Martin

This study investigates how the nucleation and elongation rates of the formin Fus1 affect the formation of the actin fusion focus in fission yeast, showing that native rates are optimal for this structure.

bioRxiv · Mar 24, 2022Cell Biology

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

J. D. Winkelman, C. A. Anderson, C. Suarez, D. R. Kovar, M. L. Gardel

This study identifies a conserved mechanism by which LIM domains bind stressed actin filaments across species, revealing their role in sensing mechanical strain.

bioRxiv · Mar 6, 2020Cell Biology

Chlamydomonas reinhardtii formin FOR1 and profilin PRF1 are optimized for acute rapid actin filament assembly

J. R. Christensen, E. W. Craig, M. J. Glista, D. M. Mueller, Y. Li, J. A. Sees, S. Huang, L. J. Mets, D. R. Kovar, P. Avasthi

This study identifies FOR1 and PRF1 in Chlamydomonas reinhardtii as key regulators of rapid F-actin assembly for fertilization tubule formation.

bioRxiv · Jul 20, 2019Cell Biology

Mechanical and kinetic factors drive sorting of F-actin crosslinkers on bundles

S. L. Freedman, C. Suarez, J. D. Winkelman, D. R. Kovar, G. A. Voth, A. R. Dinner, G. M. Hocky

The paper investigates how mechanical and kinetic factors influence the sorting of F-actin crosslinkers on bundles, showing a non-monotonic dependence on polymerization rate.

bioRxiv · Dec 11, 2018Biophysics

Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin

A. J. Harker, H. H. Katkar, T. C. Bidone, F. Aydin, G. A. Voth, D. A. Applewhite, D. R. Kovar

This study shows Ena/VASP tetramers enhance processivity on fascin-bundled actin filaments through avidity, increasing run length with more filaments and arms.

bioRxiv · Aug 7, 2018Cell Biology

Cofilin Drives Rapid Turnover and Fluidization of Entangled F-actin

P. M. McCall, F. C. MacKintosh, D. R. Kovar, M. L. Gardel

This paper shows cofilin-mediated severing of F-actin accelerates turnover and stress relaxation in entangled solutions, tuning viscosity over two orders of magnitude.

bioRxiv · Jun 26, 2017Biophysics

Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates

P. M. McCall, S. Srivastava, S. L. Perry, D. R. Kovar, M. L. Gardel, M. V. Tirrell

This study shows actin partitions into and polymerizes faster in polypeptide coacervates, suggesting coacervates can act as bioreactors for studying biomolecular reactions.

bioRxiv · Jun 19, 2017Biophysics