A. R. Richardson

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

Adaptation to overflow metabolism by mutations that impair tRNA modification in experimentally evolved bacteria

The paper shows that mutations in tilS, which impair tRNA modification, enhance bacterial growth under oxidative overflow metabolism by reducing lag phase duration.

Novel Requirement for Staphylococcal Cell Wall-Anchored Protein SasD in Pulmonary Infection

This study identifies SasD, a cell wall-anchored protein in S. aureus, as a novel virulence factor that influences inflammatory signaling and outcomes in pulmonary infections, particularly in the context of super-infection with influenza.

The nutritional environment is sufficient to select coexisting biofilm and quorum-sensing mutants of Pseudomonas aeruginosa

This study shows that nutrient conditions and biofilm selection alone can drive the evolution of Pseudomonas aeruginosa mutants with clinical phenotypes like increased biofilm and altered quorum sensing.

Genotypic diversity between surgical and nasal Staphylococcus aureus isolates

The paper compares genotypic diversity between nasal and surgical Staphylococcus aureus isolates, finding greater diversity in PJI isolates and associations with immune status and virulence.

The Toxin Antitoxin MazEF Drives Staphylococcus aureus Chronic Infection

This study shows that the MazEF toxin-antitoxin system in S. aureus inhibits biofilm formation and promotes antibiotic tolerance, facilitating the transition from acute to chronic infection.