A. Rahimi

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

Potassium homeostasis and signaling as a determinant of Echinacea species tolerance to salinity stress

The study assesses K+ retention and salinity stress tolerance in four Echinacea species, finding higher K+ efflux in E. pallida and E. sanguinea under NaCl and ROS conditions.

Key role of auxin cellular accumulation in totipotency and pluripotency acquisition

This study shows that using natural auxins with auxin transport inhibitor NPA improves plant regeneration efficiency in Arabidopsis and Brassica napus.

Endogenous auxin directs development of embryonic stem cells into somatic proembryos in Arabidopsis

This study shows that auxin biosynthesis and polar transport are essential for somatic proembryo development and differentiation in Arabidopsis after embryonic competence is acquired.

A novel pathway controlling cambium initiation and -activity via cytokinin biosynthesis in Arabidopsis

This study identifies AHL15 as a key regulator of vascular cambium activity and secondary xylem formation in Arabidopsis through cytokinin biosynthesis.

miR156-independent repression of the ageing pathway bylongevity-promoting AHL proteins in Arabidopsis

This study shows AHL15 and its family members repress the SPL-driven ageing pathway in Arabidopsis, delaying vegetative phase change and flowering time independently of miR156/157.

An Arabidopsis AT-hook motif nuclear protein mediates somatic embryogenesis and coinciding genome duplication

This study shows AHL15 overexpression induces somatic embryogenesis in Arabidopsis without hormones and leads to polyploid plants through endomitosis during SE initiation.

A suppressor of axillary meristem maturation promotes longevity in flowering plants

This study identifies AHL15 as a suppressor of axillary meristem maturation that promotes plant longevity in Arabidopsis and tobacco by extending lifespan through delayed meristem maturation.

High-yield Production of Recombinant Platelet Factor 4 Protein by Harnessing and Honing the Gram-negative Bacterial Secretory Apparatus

This study develops a method to produce recombinant platelet factor 4 (PF4) using the type II secretory pathway in E. coli, achieving high yields and structural fidelity.

Analysis of a Novel Bioreactor Designed for Ultrasound Stimulation of Cell-Seeded Scaffolds

This study designs and evaluates a novel bioreactor for ultrasound treatment of cell-seeded scaffolds, showing controlled acoustic pressure distribution through optimized geometry and acoustic materials.