Specific cholesterol binding drives drastic structural alterations in Apolipoprotein A1
A. Ray, A. Ghosh, R. Chakraborty, S. K. Upadhyay, S. Maiti, S. Sengupta, L. Thukral
This study identifies specific cholesterol binding sites in ApoA1 that drive structural changes from closed to open conformations, revealing a mechanism for cholesterol sequestration.
bioRxiv · Sep 23, 2018Biophysics