R. Chakraborty

Genomic and environmental controls on Castellaniella biogeography in an anthropogenically disturbed subsurface

This study investigates how genomic and environmental factors influence the distribution of Castellaniella species in a contaminated subsurface, identifying genetic mechanisms underlying their adaptation to stress.

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

Biomimetic Lipid-polymer composite membrane model to study Permeability through Cornea

This paper introduces a biomimetic lipid-polymer composite membrane model to study drug permeability through the cornea, showing it matches excised corneal permeation data.

Fermented polyherbal formulation restored ricinoleic acid-induced diarrhea in Sprague Dawley rats and exhibited in vitro antibacterial effect on multiple antibiotics resistant gastric pathogens

This paper evaluates a polyherbal formulation AP-01 for treating ricinoleic acid-induced diarrhea in rats and demonstrates its in vitro antibacterial activity against antibiotic-resistant gastric pathogens.

Fermented polyherbal formulation ameliorates the severity of acute multiple - antibiotics - resistant Pseudomonas aeruginosa infected burn wound in rat burn model

This paper evaluates a fermented polyherbal formulation's efficacy in reducing burn wound severity caused by multiple-antibiotic-resistant Pseudomonas aeruginosa in a rat model.

Decoding Root Biogeography: Building Reduced Complexity Functional Rhizosphere Microbial Consortia

This study develops reduced complexity rhizosphere microbial consortia by enriching root-associated microbes from Brachypodium using carbon substrates, revealing their stability and functional roles in plant growth promotion.

Iodidimonas, a bacterium unable to degrade hydrocarbons, thrives in a bioreactor treating oil and gas produced water

The paper characterizes Iodidimonas isolates from a bioreactor treating oil and gas produced water, showing they lack hydrocarbon degradation genes but have stress mitigation genes.

Fine scale sampling reveals spatial heterogeneity of rhizosphere microbiome in young Brachypodium plants

The paper examines spatial microbial heterogeneity in Brachypodium roots using EcoFABs, revealing distinct microbial communities at root tips and bases with different functional gene profiles.

Tunneling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria

This study shows that tunneling nanotubes between neurons and microglia enable bidirectional transfer of α-Synuclein and mitochondria, with implications for neurodegenerative disease spread.

Thermal endurance by a hot-spring-dwelling phylogenetic relative of the mesophilic Paracoccus

This study identifies a thermophilic strain SMMA_5, a phylogenetic relative of Paracoccus, capable of surviving high temperatures and shows how thermal conditioning and environmental solutes enhance its thermal endurance.

Age of the bone marrow dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque

This study shows that aged bone marrow-derived cells increase smooth muscle cell polyclonality in atherosclerotic plaques through reduced TET2 and increased TNF signaling.

TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma

The paper investigates TRPA1 expression in oral cancer cell lines and normal cells, finding TRPA1 absent in cancer cells, suggesting its potential as a prognostic indicator.

Pseudomonas syringae pv. tomato DC3000 Effector HopG1 is a multi-faceted protein that Triggers Necrotic Cell Death that is attenuated by the Nonhost Resistance 2B (AtNHR2B) Protein

This study identifies HopG1 as a T3SE that induces necrotic cell death and shows that AtNHR2B inhibits its virulence functions in Arabidopsis.

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

Biofilm Interaction Mapping and Analysis (BIMA): A tool for deconstructing interspecific interactions in co-culture biofilms

The paper introduces BIMA, a method to analyze interspecific interactions in biofilm co-cultures by examining colony morphology, inhibition, invasion, and associated genes/metabolites.

Ecogenomics of groundwater viruses suggests niche differentiation linked to specific environmental tolerance

The paper identifies 41 viral clusters in groundwater plasmidomes, links them to bacterial hosts, and detects novel phage genera and host-specific genes.

A defined medium based on R2A for cultivation and exometabolite profiling of soil bacteria

The paper develops a defined medium (NLDM) for cultivating soil bacteria and profiling exometabolites, showing it supports growth of 53 diverse isolates and enables metabolite tracking via LC-MS/MS.

Conservation of isolate substrate preferences in mixed communities revealed through ribosomal marker protein profiling

The paper uses ribosomal marker protein profiling to show that isolate substrate preferences are conserved in a synthetic soil community and can be predicted by a weighted-sum model.

Measurement of Volatile Compounds for Real-time Analysis of Soil Microbial Metabolic Response to Simulated Snowmelt

This study uses PTR-TOF-MS to analyze microbial volatile compounds during simulated snowmelt, revealing metabolic responses and interactions in soil microbiomes.

Identification and characterization of novel plasma proteins in drug resistant HIV/AIDS patients by SWATH-MS

This study identifies and characterizes novel plasma proteins differentially expressed in drug-resistant HIV/AIDS patients using SWATH-MS.

Systematic Discovery of Pseudomonad Genetic Factors Involved in Sensitivity to Tailocins

This study identifies genetic factors in pseudomonads that influence sensitivity to tailocins using transposon libraries and genomics.

Culturing of "Unculturable" Subsurface Microbes: Natural Organic Carbon Source Fuels the Growth of Diverse and Distinct Bacteria from Groundwater

This study shows that complex natural organic carbon sources better enrich diverse subsurface bacteria than simple organic sources.

Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

No change in oxytocin level before a human intergroup competition: study among Polish players before rugby and handball matches

This study measures urinary oxytocin levels in rugby and handball players before and during matches, finding no change in levels over time but differences between sports types.

Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin

The paper examines how sedimentation rates and organic matter dynamics influence microbiome structure and function in different oxygen minimum zones along the Arabian Sea margin.

In-field bioreactors demonstrate dynamic shifts in microbial communities in response to geochemical perturbations.

The paper demonstrates that microbial communities in in-field bioreactors shift dynamically in response to geochemical perturbations, with significant changes in taxa composition and similarity to contaminated well communities.

Structural analysis of Sub16 sedolisin of Trichophyton rubrum reveals a flexible nature of its pro domain

The paper investigates the structural flexibility of the pro domain of Sub16, a sedolisin from T. rubrum, showing it is stabilized when complexed with the catalytic domain.

Metabolically-active obligate aerobes in anoxic (sulfidic) marine sediments

The paper identifies metabolically-active obligate aerobes in anoxic marine sediments by combining culture-dependent and -independent methods, revealing their survival through cryptic oxygen production.

Inorganic salts and compatible solutes help mesophilic bacteria inhabit the high temperature waters of a Trans-Himalayan sulfur-borax spring

The paper investigates how inorganic salts and compatible solutes enable mesophilic bacteria to thrive in high-temperature Trans-Himalayan hot springs by stabilizing macromolecules and maintaining cell viability.

Heme minimizes Parkinson’s disease-associated toxicity by inducing a conformational distortion in the oligomers of alpha-Synuclein

This study shows heme reduces alpha-Synuclein toxicity by altering its oligomer structure, preventing harmful fibril formation.