Author

A. A. Rao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:clustering· 2

Frequent Co-Authors

M. F. Krummel· 7 shared A. J. Combes· 5 shared B. Samad· 4 shared J. Tsui· 4 shared T. Courau· 4 shared V. Chan· 4 shared D. J. Erle· 3 shared G. K. Fragiadakis· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

M. F. Krummel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function

O. A. Bolonduro, Z. Chen, Y.-R. Lai, M. Cote, A. A. Rao, H. Liu, E. S. Tzanakakis, B. P. Timko

This paper introduces an integrated optogenetic and bioelectronic platform to modulate and monitor cardiomyocyte function in vitro, showing a 14% increase in beat rate with blue light stimulation.

bioRxiv · Dec 15, 2023Bioengineering

Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data

R. K. Patel, R. G. Jaszczak, I. Kwok, N. D. Carey, T. Courau, D. Bunis, B. Samad, L. Avanesyan, N. W. Chew, S. Stenske, J. M. Jespersen, J. Publicover, A. Edwards, M. Naser, A. A. Rao, , G. K. Fragiadakis

Cyclone is a pipeline for analyzing, evaluating, and optimizing multiparametric cytometry data, demonstrating effectiveness across multiple cytometry technologies and biological contexts.

bioRxiv · Mar 8, 2023 · PreprintImmunology

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

K. Kersten, K. H. Hu, A. J. Combes, B. Samad, T. Harwin, A. Ray, A. A. Rao, E. Cai, K. Marchuk, J. Artichoker, T. Courau, Q. Shi, J. Belk, A. T. Satpathy, M. F. Krummel

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

bioRxiv · Sep 27, 2021Cancer Biology

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

A. M. Mujal, A. J. Combes, A. A. Rao, M. Binnewies, B. Samad, J. Tsui, A. Boissonnas, J. L. Pollack, R. J. Arguello, M. K. Ruhland, K. C. Barry, V. Chan, M. F. Krummel

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

bioRxiv · Jul 7, 2021Immunology

Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease

J. R. Kratz, J. Z. Li, J. Tsui, J. C. Lee, V. W. Ding, A. A. Rao, M. J. Mann, V. Chan, A. R. Combes, M. F. Krummel, D. M. Jablons

This study identifies distinct genetic and immunologic features of recurrent stage I lung adenocarcinoma using multiomic profiling and single-cell RNA-seq.

bioRxiv · May 20, 2021 · PreprintCancer Biology

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

A. J. Combes, B. Samad, J. Tsui, N. W. Chew, P. Yan, G. C. Reeder, D. Kushnoor, A. Shen, B. Davidson, A. J. Barczac, M. Adkisson, A. Edwards, M. Naser, K. C. Barry, T. Courau, , M. F. Krummel

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology