Author

A. Schwab

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. Ceppi· 3 shared P. N. Gollavilli· 3 shared B. Parma· 2 shared F. Ehlicke· 2 shared I. A. Asangani· 2 shared M. E. Vazakidou· 2 shared M. Volante· 2 shared O. Saatci· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

P. Ceppi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels

I. Budde, A. Schlichting, D. Ing, S. Schimmelpfennig, A. Kuntze, B. Fels, J. M.-J. Romac, S. M. Swain, R. A. Liddle, A. Stevens, A. Schwab, Z. Petho

This study identifies Piezo1, TRPC1, and TRPV4 as mechanosensitive ion channels crucial for durotaxis in pancreatic stellate cells, which contributes to pancreatic cancer progression.

bioRxiv · Dec 22, 2023Physiology

Metabolic breakdown of non-small cell lung cancers by mitochondrial HSPD1 targeting

B. Parma, V. Ramesh, P. N. Gollavilli, A. M. Siddiqui, L. Pinna, A. Schwab, S. Marshall, S. Zhang, C. Pilarsky, F. Napoli, M. Volante, S. Urbanczyk, D. Mielenz, H. D. Schroeder, M. Stemmler, , P. Ceppi

This study identifies HSPD1 as a therapeutic target in NSCLC, showing its disruption leads to metabolic breakdown and suppressed tumor growth.

bioRxiv · Mar 9, 2021Cancer Biology

Ex vivo osteochondral test system with control over cartilage defect depth - a pilot study to investigate the effect of oxygen tension and chondrocyte-based treatments in chondral and full thickness defects in an organ model

A. Schwab, A. Buss, O. Pullig, F. Ehlicke

This study uses an automated device to create controlled cartilage defects in porcine osteochondral explants and investigates how oxygen tension and cell treatments affect cartilage repair.

bioRxiv · Nov 6, 2020 · PreprintCell Biology

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

M. A. Siddiqui, P. N. Gollavilli, V. Ramesh, B. Parma, A. Schwab, M. E. Vazakidou, R. Natesan, O. Saatci, I. Rapa, P. Bironzo, H. Schuhwerk, I. A. Asangani, O. Sahin, M. Volante, P. Ceppi

This study identifies thymidylate synthase (TS) as a driver of epithelial-to-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC), linking it to metastasis, chemotherapy resistance, and survival.

bioRxiv · Aug 13, 2020Cancer Biology

Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell morphology and alignment.

A. Schwab, C. Helary, R. G. Richards, M. Alini, D. O. Eglin, M. D'Este

This paper develops a bioink with aligned collagen fibers that modulate cell morphology and promote chondrogenic differentiation in human mesenchymal stromal cells.

bioRxiv · Feb 26, 2020 · PreprintBioengineering

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers

A. Siddiqui, P. N. Gollavilli, A. Schwab, M. E. Vazakidou, P. Ersan, M. Ramakrishnan, D. Pluim, S. A. Coggins, O. Saatci, L. Annaratone, J. H. Schellens, B. Kim, I. A. Asangani, S. A. K. Rasheed, C. Marchio, , P. Ceppi

This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.

Cell Death & Differentiation · Nov 1, 2019Peer-reviewedCancer Biology

Inducing Chondrogenesis In MSC/Chondrocyte Co-Cultures Using Exogenous TGF-β: A Mathematical Model

M. Chen, J. Whiteley, C. Please, A. Schwab, F. Ehlicke, S. Waters, H. Byrne

This paper develops a mathematical model to compare strategies for inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β, showing critical thresholds for complete differentiation.

bioRxiv · Oct 1, 2017Bioengineering