D. Mielenz

Systematic mapping of MCU-mediated mitochondrial calcium signaling networks

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology

This study uses proteomics and lipidomics to analyze TFG-deficient B cells, identifying TFG's role in autophagy, plasma cell biology, and lipid homeostasis.

The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response

This study shows that DGCR8 is essential for T cell-dependent germinal center responses and antibody production, but not for B-1 cell functions.

A pair of non-competing neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

The paper identifies two clusters of non-competing neutralizing antibodies against SARS-CoV-2 that protect mice from infection and weight loss.

Metabolic breakdown of non-small cell lung cancers by mitochondrial HSPD1 targeting

This study identifies HSPD1 as a therapeutic target in NSCLC, showing its disruption leads to metabolic breakdown and suppressed tumor growth.

Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells

This study shows that mitochondrial function is critical for B cell differentiation into plasma cells by regulating TCA cycle flux, phosphatidic acid levels, and mTOR activity.

The Trk fused gene-product (Tfg) is part of a 600-700kDa CARMA1 complex

The paper identifies Tfg as a new interaction partner of the CARMA1 complex and characterizes the size of CARMA1 complexes.