Author

J. P. Tam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2 Plant Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:plant (other)· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Kam· 3 shared S. Loo· 3 shared X. Hemu· 3 shared X. Zhang· 3 shared B. Dutta· 2 shared C.-F. Liu· 2 shared J. Lescar· 2 shared S. Hu· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Kam

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ginsentide TP1 Protects Hypoxia-Induced Dysfunction and ER Stress-Linked Apoptosis

B. Dutta, S. Loo, A. Kam, S. K. Sze, J. P. Tam

This study shows ginsentide TP1 protects human endothelial cells from hypoxia-induced dysfunction and ER stress-linked apoptosis by restoring NO signaling, reducing oxidative stress, and preventing endothelial activation.

bioRxiv · Apr 12, 2023 · PreprintPharmacology & Toxicology

Decoding the Cure-all Effects of Ginseng

S. Loo, A. Kam, B. Dutta, X. Zhang, N. Feng, S. K. Sze, C.-F. Liu, X. Wang, J. P. Tam

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

bioRxiv · Apr 5, 2023 · PreprintPharmacology & Toxicology

Consensus design and engineering of an efficient and high-yield Peptide Asparaginyl Ligase

X. Hemu, X. Zhang, H. Y. Chang, J. E. Poh, J. P. Tam

The paper designs and engineers a high-yield, efficient recombinant peptide asparaginyl ligase (PAL) by modifying a consensus legumain sequence and applying the LAD hypothesis.

bioRxiv · Nov 2, 2022 · PreprintBiochemistry

Substrate-binding Glycine Residues are Major Determinants for Hydrolase and Ligase Activity of Plant Legumains

X. Hemu, N.-Y. Chan, H. T. Liew, S. Hu, X. Zhang, A. Serra, J. Lescar, C.-F. Liu, J. P. Tam

The paper identifies conserved glycine residues as key determinants distinguishing peptide asparaginyl ligases (PALs) from asparaginyl endopeptidases (AEPs) in plant legumains.

bioRxiv · Sep 26, 2022Plant Biology

Genomic, transcriptomic, and metabolomic analysis of Traditional Chinese Medicine plant Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

I. Julca, D. Mutwil-Anderwald, V. Manoj, Z. Khan, S. K. Lai, L. K. Yang, I. T. Beh, J. Dziekan, Y. P. Lim, S. K. Lim, Y. W. Low, Y. I. Lam, Y. Mu, Q. W. Tan, P. Nuc, , M. Mutwil

This study identifies ursolic acid as the main anti-cancer compound in Oldenlandia corymbosa and reveals its mode of action through genomic, transcriptomic, and metabolomic analysis.

bioRxiv · Jun 14, 2022 · PreprintPlant Biology

Structural basis for substrate recognition, ligation and activation by a hyperactive Asn peptide ligase from Viola yedoensis

J. Lescar, S. Hu, A. El Sahili, S. Kishore, X. Hemu, C. F. Liu, J. P. Tam, B. C. Goh, Y. H. Wong, Z. Wang

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

bioRxiv · Dec 9, 2021 · PreprintBiochemistry