Author

X. Hemu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

J. P. Tam· 3 shared J. Lescar· 2 shared S. Hu· 2 shared X. Zhang· 2 shared A. El Sahili· 1 shared A. Serra· 1 shared B. C. Goh· 1 shared C. F. Liu· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

J. P. Tam

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3 papers

Recent·Most cited

Consensus design and engineering of an efficient and high-yield Peptide Asparaginyl Ligase

X. Hemu, X. Zhang, H. Y. Chang, J. E. Poh, J. P. Tam

The paper designs and engineers a high-yield, efficient recombinant peptide asparaginyl ligase (PAL) by modifying a consensus legumain sequence and applying the LAD hypothesis.

bioRxiv · Nov 2, 2022 · PreprintBiochemistry

Substrate-binding Glycine Residues are Major Determinants for Hydrolase and Ligase Activity of Plant Legumains

X. Hemu, N.-Y. Chan, H. T. Liew, S. Hu, X. Zhang, A. Serra, J. Lescar, C.-F. Liu, J. P. Tam

The paper identifies conserved glycine residues as key determinants distinguishing peptide asparaginyl ligases (PALs) from asparaginyl endopeptidases (AEPs) in plant legumains.

bioRxiv · Sep 26, 2022Plant Biology

Structural basis for substrate recognition, ligation and activation by a hyperactive Asn peptide ligase from Viola yedoensis

J. Lescar, S. Hu, A. El Sahili, S. Kishore, X. Hemu, C. F. Liu, J. P. Tam, B. C. Goh, Y. H. Wong, Z. Wang

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

bioRxiv · Dec 9, 2021 · PreprintBiochemistry