Author

A. Sierra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Plaza-Zabala· 2 shared V. Sierra-Torre· 2 shared A. Bruna· 1 shared A. Celma· 1 shared A. Martinez-Aranda· 1 shared A. Petit· 1 shared A. R. Green· 1 shared A. Santamaria· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

A. Plaza-Zabala

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: overfitting or meaningful parameter?

M. Yon, O. Narvaez, J. Martin, H. Jiang, D. Bernin, E. Forssell-Aronsson, F. Laun, A. Sierra, D. Topgaard

This study investigates whether frequency-dependent diffusion-relaxation MRI can provide meaningful information or if it leads to overfitting in different tissue types and frequency ranges.

bioRxiv · Apr 29, 2024 · PreprintBiophysics

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

I. Casanova-Salas, S. Cordoba-Terreros, D. Aguilar, L. Agundez, J. Brandariz, N. Herranz, M. Gonzalez, R. Morales-Barrera, A. Sierra, M. Soriano-Navarro, P. Cresta, S. Simonetti, G. Rodrigues, S. Arce-Gallego, L. Delgado, , J. Mateo

This study shows that circulating tumor extracellular vesicles can be used to monitor genomic and transcriptomic changes in metastatic prostate cancer through liquid biopsy.

bioRxiv · Apr 14, 2023Cancer Biology

RANK is an independent biomarker of poor prognosis in estrogen receptor-negative breast cancer and a therapeutic target in patient-derived xenografts

M. Ciscar, E. M. Trinidad, H. Perez-Montoyo, M. Alsaleem, M. J. Jimenez-Santos, M. Toss, A. Sanz-Moreno, A. Vethencourt, G. Perez-Chacon, A. Petit, M. T. Soler-Monso, J. Gomez-Miragaya, C. Gomez-Aleza, M. Jimenez, L. E. Dobrolecki, , E. Gonzalez-Suarez

This study shows RANK is a poor prognosis biomarker in ER-negative breast cancer and that targeting RANK improves outcomes in patient-derived xenografts.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

A two-step model of autophagy: autophagosome formation, degradation and net turnover

A. Plaza-Zabala, V. Sierra-Torre, A. Sierra

The paper proposes a two-step model of autophagy to analyze formation and degradation using LC3-II Western blot data in microglia, testing it with rapamycin and MRT68921.

bioRxiv · Sep 29, 2020 · PreprintCell Biology

Microglia actively remodels adult hippocampal neurogenesis through the phagocytosis secretome

I. Diaz-Aparicio, I. Paris, V. Sierra-Torre, A. Plaza-Zabala, N. Rodriguez-Iglesias, M. Marquez-Ropero, S. Beccari, O. Abiega, E. Alberdi, C. Matute, I. Bernales, A. Schulz, L. Otrokocsi, B. Sperlagh, K. E. Happonen, , A. Sierra

The paper shows that microglia's phagocytic activity regulates adult hippocampal neurogenesis by modulating neuron production through their secretome.

bioRxiv · Mar 29, 2019Cell Biology