L. Wagner

Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity

This study shows that the Arp2/3 complex is essential for lysosomal integrity during autophagy, as its absence leads to lysosomal damage and impaired autophagic flux.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

Loss of STIM1 and STIM2 in salivary glands disrupts ANO1 function but does not induce Sjogren's disease

This study shows that loss of STIM1 and STIM2 in salivary glands reduces ANO1 function and saliva production but does not cause Sjogren's disease, suggesting a link between SOCE and TLR8 signaling.

An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma

This study identifies an autoregulatory feedback loop involving H2A ubiquitination that enhances SS18-SSX fusion protein chromatin binding and oncogenic activity in synovial sarcoma.

Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells

This study investigates the role of RTN1A in dendrite dynamics and immune functions of human Langerhans cells, showing that RTN1A inhibition causes dendrite retraction and affects immune responses.

Preclinical establishment of a divalent vaccine against SARS-CoV-2

This paper develops a divalent vaccine against SARS-CoV-2 that induces strong IgG responses and T-cell activation, showing durability and cross-variant protection.

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL

This paper maps drug-microenvironment interactions in CLL to identify resistance mechanisms and patient subgroups, revealing how microenvironmental stimuli and genetic alterations influence drug response.

Social signaling via bioluminescent blinks drives schooling behavior in the flashlight fish Anomalops katoptron

The study shows that bioluminescent blink patterns in flashlight fish influence schooling behavior by altering swimming speed, nearest neighbor distance, and alignment with light sources.