Author

F. J. Sanchez-Rivera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:genetic perturbation / CRISPR· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3

Frequent Co-Authors

S. W. Lowe· 6 shared A. F. Stenzel· 3 shared A. Peace· 3 shared A. W. Ashbrook· 3 shared C. M. Rice· 3 shared E. Michailidis· 3 shared H.- H. Hoffmann· 3 shared I. Ricardo-Lax· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCancer Biology

S. W. Lowe

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

J. Le Pen, G. Paniccia, V. Kinast, M. Moncada-Velez, A. W. Ashbrook, M. Bauer, H.- H. Hoffmann, A. Pinharanda, I. Ricardo-Lax, A. F. Stenzel, E. A. Rosado-Olivieri, K. H. Dinnon, W. C. Doyle, C. A. Freije, S.-H. Hong, , C. M. Rice

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

bioRxiv · Feb 16, 2024Immunology

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

D. Karagiannis, W. Wu, A. Li, M. Hayashi, X. Chen, M. Yip, V. Mangipudi, X. Xu, F. J. Sanchez-Rivera, Y. M. Soto-Feliciano, J. Ye, T. Papagiannakopoulos, C. Lu

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

bioRxiv · Apr 24, 2023 · PreprintCancer Biology

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

A. Katti, M. Foronda, J. Zimmermann, M. P. Zafra, S. Goswami, E. E. Gardner, B. J. Diaz, J. M. Simon, A. Wuest, W. Luan, M. T. C. Fernandez, A. P. Kadina, J. A. Walker, K. Holden, F. J. Sanchez-Rivera, , L. E. Dow

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma

N. S. Benabdallah, V. Dalal, A. Sotiriou, R. W. Scott, F. K. Kommoss, A. Pejkovska, L. Gaspar, L. Wagner, F. J. Sanchez-Rivera, M. Ta, S. Thornton, T. O. Nielsen, T. M. Underhill, A. Banito

This study identifies an autoregulatory feedback loop involving H2A ubiquitination that enhances SS18-SSX fusion protein chromatin binding and oncogenic activity in synovial sarcoma.

bioRxiv · Jul 18, 2022 · PreprintCancer Biology

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

J. Leibold, C. Amor, K. M. Tsanov, Y.-J. Ho, F. J. Sanchez-Rivera, J. Feucht, T. Baslan, H.-A. Chen, S. Tian, J. Simon, A. Wuest, J. E. Wilkinson, S. W. Lowe

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

bioRxiv · Jun 15, 2022Cancer Biology

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

bioRxiv · Oct 22, 2021Cancer Biology

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

W. M. Schneider, J. M. Luna, H.- H. Hoffmann, F. J. Sanchez-Rivera, A. A. Leal, A. W. Ashbrook, J. Le Pen, E. Michailidis, I. Ricardo-Lax, A. Peace, A. F. Stenzel, S. W. Lowe, M. R. MacDonald, C. M. Rice, J. T. Poirier

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

bioRxiv · Oct 7, 2020Microbiology

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

H.- H. Hoffmann, W. M. Schneider, F. J. Sanchez-Rivera, J. M. Luna, A. W. Ashbrook, Y. M. Soto-Feliciano, A. A. Leal, J. Le Pen, I. Ricardo-Lax, E. Michailidis, Y. Hao, A. F. Stenzel, A. Peace, C. D. Allis, S. W. Lowe, , C. M. Rice

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

bioRxiv · Sep 11, 2020Microbiology