Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism
A. L. Marcinkiewicz, K. Brangulis, A. P. Dupuis, T. M. Hart, M. Zamba_Campero, T. A. Nowak, J. L. Stout, I. Akopjana, A. Kazaks, J. Bogans, A. T. Ciota, P. Kraiczy, S.-O. Kolokotronis, Y.-P. Lin
This paper identifies a minor sequence variation in the CspZ protein of Borrelia burgdorferi that influences host-specific complement evasion and infectivity through FH-binding interface differences.
bioRxiv · Sep 13, 2022 · PreprintMicrobiology