Author

A. P. Dupuis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:mouse· 4 Assay:proteomics· 3 Organism:human· 2 Assay:metagenomics· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

Y.-P. Lin· 4 shared A. L. Marcinkiewicz· 3 shared J. L. Stout· 3 shared M. A. Diuk-Wasser· 3 shared S.-O. Kolokotronis· 3 shared A. D. Davis· 2 shared A. M. Blom· 2 shared A. T. Ciota· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

Y.-P. Lin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism

A. L. Marcinkiewicz, K. Brangulis, A. P. Dupuis, T. M. Hart, M. Zamba_Campero, T. A. Nowak, J. L. Stout, I. Akopjana, A. Kazaks, J. Bogans, A. T. Ciota, P. Kraiczy, S.-O. Kolokotronis, Y.-P. Lin

This paper identifies a minor sequence variation in the CspZ protein of Borrelia burgdorferi that influences host-specific complement evasion and infectivity through FH-binding interface differences.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae host association

M. A. Combs, A. L. Marcinkiewicz, A. P. Dupuis, A. D. Davis, P. Lederman, T. A. Nowak, J. L. Stout, K. Strle, V. Fingerle, G. Margos, A. T. Ciota, M. A. Diuk-Wasser, S.-O. Kolokotronis, Y.-P. Lin

This study investigates how genetic variation in Lyme disease-causing Borrelia burgdorferi strains relates to their ability to evade host complement immune responses, revealing host-specific complement-evasion phenotypes.

bioRxiv · May 25, 2022Microbiology

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

T. M. Hart, A. P. Dupuis, D. M. Tufts, A. M. Blom, S. Starkey, R. O. M. Rego, S. Ram, P. Kraiczy, L. D. Kramer, M. A. Diuk-Wasser, S.-O. Kolokotronis, Y.-P. Lin

The paper identifies CspA as a determinant of host tropism in Lyme disease bacteria, showing convergent evolution drives transmission differences among vertebrates.

bioRxiv · Feb 9, 2021Microbiology

Host specialization in microparasites transmitted by generalist vectors: insights into the cellular and immunological mechanisms

Y.-P. Lin, D. M. Tufts, A. P. Dupuis, M. Combs, A. L. Marcinkiewicz, A. D. Hirsbrunner, A. J. Diaz, J. L. Stout, A. M. Blom, K. Strle, A. D. Davis, L. D. Kramer, M. A. Diuk-Wasser

This study investigates host specialization in Lyme disease bacteria by testing different genotypes in reservoir hosts, finding that bacterial persistence depends on adhesion and immune evasion traits.

bioRxiv · Nov 13, 2020 · PreprintMicrobiology

A simple protein-based surrogate neutralization assay for SARS-CoV-2

K. T. Abe, Z. Li, R. Samson, P. Samavarchi-Tehrani, E. J. Valcourt, H. Wood, P. Budylowski, A. P. Dupuis, R. C. Girardin, B. Rathod, K. Colwill, A. J. McGeer, S. Mubareka, J. L. Gommerman, Y. Durocher, , A.-C. Gingras

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

bioRxiv · Jul 10, 2020Immunology