Author

T. M. Hart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

A. P. Dupuis· 2 shared P. Kraiczy· 2 shared S.-O. Kolokotronis· 2 shared Y.-P. Lin· 2 shared A. Kazaks· 1 shared A. L. Marcinkiewicz· 1 shared A. M. Blom· 1 shared A. T. Ciota· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

A. P. Dupuis

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2 papers

Recent·Most cited

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism

A. L. Marcinkiewicz, K. Brangulis, A. P. Dupuis, T. M. Hart, M. Zamba_Campero, T. A. Nowak, J. L. Stout, I. Akopjana, A. Kazaks, J. Bogans, A. T. Ciota, P. Kraiczy, S.-O. Kolokotronis, Y.-P. Lin

This paper identifies a minor sequence variation in the CspZ protein of Borrelia burgdorferi that influences host-specific complement evasion and infectivity through FH-binding interface differences.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

T. M. Hart, A. P. Dupuis, D. M. Tufts, A. M. Blom, S. Starkey, R. O. M. Rego, S. Ram, P. Kraiczy, L. D. Kramer, M. A. Diuk-Wasser, S.-O. Kolokotronis, Y.-P. Lin

The paper identifies CspA as a determinant of host tropism in Lyme disease bacteria, showing convergent evolution drives transmission differences among vertebrates.

bioRxiv · Feb 9, 2021Microbiology