Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation
S. Shee, S. Singh, A. Tripathi, C. Thakur, A. T. Kumar, M. Das, V. Yadav, S. Kohli, R. S. Rajmani, N. Chandra, H. Chakrapani, K. drlica, A. Singh
This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.
bioRxiv · Apr 4, 2022 · PreprintMicrobiology