C. Thakur

Guggulsterone Enhances NKX3.1 Expression and Induces Apoptosis in Prostate Cancer Cells: Implications for Chemoprevention

This study shows Guggulsterone induces apoptosis in prostate cancer cells by increasing NKX3.1 expression and stabilizing its mRNA and protein, suggesting it as a potential chemoprevention target.

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

A simple method to determine the elimination half-life of drugs displaying noncumulative toxicity

This paper introduces TOXHL, a method to determine the elimination half-life of drugs with noncumulative toxicity using survival outcomes from three experiments.

The histidine kinase PdtaS is a cyclic di-GMP binding metabolic sensor that controls mycobacterial adaptation to nutrient deprivation

The paper identifies PdtaS as a c-di-GMP binding histidine kinase that regulates mycobacterial adaptation to nutrient deprivation through transcriptional and metabolic changes.