N. Chandra

Increased 'selfness' in the tumor emerges as a possible immune sculpting mechanism: A pan-cancer data analysis of 32 solid tumors in TCGA

The paper develops a thymus-like score to assess tumor similarity to thymi and finds it correlates with patient survival and inversely with immune infiltration across 32 solid tumors.

Regenerative Agriculture Augments Bacterial Community Structure for a Healthier Soil and Agriculture

This study compares conventional and regenerative agriculture practices, finding that regenerative methods enhance soil bacterial diversity and nutrient composition, particularly in vegetable and ragi crops.

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

A simple method to determine the elimination half-life of drugs displaying noncumulative toxicity

This paper introduces TOXHL, a method to determine the elimination half-life of drugs with noncumulative toxicity using survival outcomes from three experiments.

A uniform in vitro efficacy dataset to guide antimicrobial peptide design

The paper presents a uniform in vitro dataset of 20 antimicrobial peptides tested against 30 organisms to improve computational design by reducing data heterogeneity.

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.