A. T. Lopez-Jimenez

High-content high-resolution microscopy and deep learning assisted analysis reveals host and bacterial heterogeneity during Shigella infection

The paper uses high-resolution microscopy and deep learning to analyze host and bacterial heterogeneity during Shigella infection, revealing SEPT7 recruitment patterns linked to T3SS activation.

Septins and K63 chains form separate bacterial microdomains during autophagy of entrapped Shigella

The paper investigates how septins and K63 ubiquitin chains form separate microdomains during autophagy of Shigella, revealing their distinct recruitment during antibacterial defense.

Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive Escherichia coli

The paper shows that acquisition of the pINV plasmid in ST99 E. coli made its virulence temperature-dependent, aiding global dispersal.

An automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in vivo

The paper develops an automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in zebrafish, revealing that nalidixic acid restricts Shigella dissemination.

The developmental cycle of Dictyostelium discoideum ensures curing of a mycobacterial infection at both cell autonomous level and by collaborative exclusion

This study shows that Dictyostelium discoideum can cure mycobacterial infections through cell-autonomous mechanisms and collective exclusion during its developmental cycle.

ESCRT and autophagy cooperate to repair ESX-1-dependent damage to the Mycobacterium-containing vacuole

The paper shows that ESCRT and autophagy work together to repair damage to the Mycobacterium-containing vacuole caused by ESX-1, preventing bacterial escape.