Author

J. N. Pruneda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

T. G. Franklin· 3 shared J. V. Nguyen· 2 shared P. P. Geurink· 2 shared A. Dufner· 1 shared A. F. Schubert· 1 shared A. T. Lopez-Jimenez· 1 shared B. S. Sixt· 1 shared C. G. Roberts· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

T. G. Franklin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

P. Y. Tey, A. Dufner, K.-P. Knobeloch, J. N. Pruneda, M. J. Clague, S. Urbe

The paper investigates CTLA4 turnover, showing ubiquitylation at K203 and K213 drives lysosomal degradation, with USP8 and HD-PTP modulating this process through distinct mechanisms.

bioRxiv · Dec 31, 2023Cell Biology

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

T. G. Franklin, P. S. Brzovic, J. N. Pruneda

This study identifies and characterizes bacterial HECT-like E3 ligases, revealing structural insights into their polyUb ligation mechanism and specificity.

bioRxiv · Jun 5, 2023Biochemistry

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

R. J. Bastidas, M. Kedzior, R. K. Davidson, S. C. Walsh, L. Dolat, B. S. Sixt, J. N. Pruneda, J. Coers, R. H. Valdivia

The study shows that Cdu1's acetylase activity protects Chlamydia effectors from degradation, enabling bacterial exit from host cells.

bioRxiv · Feb 28, 2023Microbiology

Septins and K63 chains form separate bacterial microdomains during autophagy of entrapped Shigella

D. Lobato-Marquez, J. J. Conesa, A. T. Lopez-Jimenez, M. E. Divine, J. N. Pruneda, S. Mostowy

The paper investigates how septins and K63 ubiquitin chains form separate microdomains during autophagy of Shigella, revealing their distinct recruitment during antibacterial defense.

bioRxiv · Nov 14, 2022Microbiology

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin, J. V. Nguyen, P. P. Geurink, T. Kubori, H. Nagai, J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

bioRxiv · May 11, 2022Biochemistry

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin, P. P. Geurink, C. G. Roberts, D. J. Sanderson, L. N. Miller, H. Ovaa, K. Hofmann, J. N. Pruneda, D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

bioRxiv · Mar 28, 2020Biochemistry