A. T. Weeraratna

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

The paper identifies a rare invasive subpopulation of melanoma cells that drives metastasis, independent of environment, through non-genetic gene expression fluctuations.

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.