Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.
G. M. Alicea, M. E. Portuallo, P. Patel, M. E. Fane, A. Carey, D. W. Speicher, A. Kossenkov, V. W. Rebecca, D. Wirtz, A. T. Weeraratna
This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.
bioRxiv · May 2, 2023Cancer Biology