Author

V. B. Shenoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Approach:mechanistic / dynamical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2

Frequent Co-Authors

X. Chen· 4 shared P. A. Janmey· 3 shared E. Ban· 2 shared E. McEvoy· 2 shared J. A. Burdick· 2 shared R. G. Wells· 2 shared A. Dhand· 1 shared A. E. Loneker· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

X. Chen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identification of CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices

B. C. H. Cheung, X. Chen, H. J. Davis, C. S. Nordmann, J. Toth, L. Hodgson, J. E. Segall, V. B. Shenoy, M. Wu

This study identifies CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices, showing its role in modulating collagen network mechanics and tumor invasion.

bioRxiv · Oct 24, 2023 · PreprintBiophysics

Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation

A. E. Loneker, F. Alisafaei, A. Kant, P. A. Janmey, V. B. Shenoy, R. G. Wells

This study shows lipid droplets act as intracellular mechanical stressors that cause nuclear deformation and hepatocyte dedifferentiation, similar to tissue stiffening effects.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Glycosaminoglycans Modulate Long-Range Mechanical Communication Between Cells in Collagen Networks

X. Chen, D. Chen, E. Ban, P. A. Janmey, R. G. Wells, V. B. Shenoy

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.

bioRxiv · Sep 13, 2021Biophysics

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

S.-J. Heo, S. Thakur, X. Chen, C. Loebel, B. Xia, R. McBeath, J. A. Burdick, V. B. Shenoy, R. L. Mauck, M. Lakadamyali

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.

bioRxiv · Apr 27, 2021 · PreprintBioengineering

Programmable and Contractile Materials Through Cell Encapsulation in Fibrous Hydrogel Assemblies

M. D. Davidson, M. E. Prendergast, E. Ban, K. L. Xu, G. Mickel, P. Mensah, A. Dhand, P. A. Janmey, V. B. Shenoy, J. A. Burdick

This paper develops fibrous hydrogel assemblies that contract when encapsulated with mesenchymal stromal cells, enabling programmed shape changes for biofabrication and tissue engineering.

bioRxiv · Apr 19, 2021Bioengineering

Modeling the three-way feedback between cellular contractility, actin polymerization, and adhesion turnover resolves the contradictory effects of RhoA and Rac1 on endothelial junction dynamics

E. McEvoy, T. Sneh, E. Moeendarbary, G. E. Marino, X. Chen, J. Escribano, F. Spill, J. M. Garcia-Aznar, A. T. Weeraratna, T. M. Svitkina, R. D. Kamm, V. B. Shenoy

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

bioRxiv · Mar 15, 2021 · PreprintBiophysics

Gap junctions amplify spatial variations in cell volume in proliferating solid tumors

E. McEvoy, Y. Han, M. Guo, V. B. Shenoy

This study uses a mechano-osmotic model and experiments to show gap junctions amplify spatial volume variations in multicellular spheroids due to proliferation-induced solid stress.

bioRxiv · Apr 15, 2020Biophysics