Author

A. Tarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:flow cytometry· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Grifoni· 6 shared A. Sette· 6 shared J. M. Dan· 6 shared D. Weiskopf· 5 shared J. Sidney· 4 shared N. Methot· 4 shared S. Crotty· 4 shared A. Frazier· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

A. Grifoni

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6 papers

Recent·Most cited

Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses

A. Tarke, Y. Zhang, N. Methot, T. N. Narowski, E. Phillips, S. Mallal, A. Frazier, G. Filaci, D. Weiskopf, J. M. Dan, P. Lakshmanane, R. H. Scheuermann, A. Sette, A. Grifoni

This study identifies T cell epitopes and cross-reactivity patterns across common cold coronaviruses, highlighting conservation and limitations in cross-reactivity among subgenera.

bioRxiv · Jan 4, 2023Immunology

Defining antigen targets to dissect vaccinia virus (VACV) and Monkeypox virus (MPXV)-specific T cell responses in humans

A. Grifoni, Y. Zhang, A. Tarke, J. Sidney, P. Rubiro, M. Reina-Campos, G. Filaci, J. M. Dan, R. H. Scheuermann, A. Sette

The paper predicts MPXV T cell epitopes using VACV epitope data and identifies immunodominant targets to design peptide pools for detecting cross-reactive T cells in vaccinated individuals.

bioRxiv · Sep 6, 2022 · PreprintImmunology

Humoral and cellular immune memory to four COVID-19 vaccines

Z. Zhang, J. Mateus, C. H. Coelho, J. M. Dan, C. R. Moderbacher, R. I. Galvez, F. H. Cortes, A. Grifoni, A. Tarke, J. Chang, E. A. Escarrega, C. Kim, B. Goodwin, N. I. Bloom, A. Frazier, , S. Crotty

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

bioRxiv · Mar 18, 2022Immunology

SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron

A. Tarke, C. H. Coelho, Z. Zhang, J. M. Dan, E. D. Yu, N. Methot, N. I. Bloom, B. Goodwin, E. Phillips, S. Mallal, J. Sidney, G. Filaci, D. Weiskopf, R. da Silva Antunes, S. Crotty, , A. Sette

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

bioRxiv · Dec 28, 2021 · PreprintImmunology

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

A. Tarke, J. Sidney, N. Methot, Y. Zhang, J. M. Dan, B. Goodwin, P. Rubiro, A. Sutherland, R. da Silva Antunes, A. Fraizer, S. A. Rawlings, D. M. Smith, B. Peters, R. H. Scheuermann, D. Weiskopf, , A. Sette

The paper analyzes T cell responses to SARS-CoV-2 variants and finds minimal impact on CD4+ and CD8+ T cell reactivity in convalescents and vaccinees.

bioRxiv · Feb 27, 2021Immunology

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

A. Tarke, J. Sidney, C. K. Kidd, J. M. Dan, S. I. Ramirez, E. D. Yu, J. Mateus, R. da Silva Antunes, E. Moore, P. Rubiro, N. Methot, E. J. Phillips, S. Mallal, A. Frazier, S. Rawlings, , A. Sette

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.

bioRxiv · Dec 8, 2020Immunology