E. J. Phillips

PINK1 is a target of T cell responses in Parkinson's disease

The paper identifies PINK1 as an autoantigen targeted by T cells in Parkinson's disease, with reactivity predominantly observed in male patients.

Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.

Dietary restriction extends lifespan across different temperatures in the fly

This study re-tests dietary restriction's effect on fly lifespan across different temperatures, finding robust lifespan extension regardless of temperature.

CD3+ T-cell: CD14+monocyte complexes are dynamic and increased with HIV and glucose intolerance

The paper identifies increased CD3+ T-cell:CD14+ monocyte complexes in diabetes and HIV, associated with inflammation and metabolic changes.

Rapamycin not Dietary Restriction improves resilience against pathogens: a meta-analysis

This paper compares the effects of rapamycin and dietary restriction on post-infection survival in mice using meta-analysis, finding rapamycin improves survival while DR reduces it.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

This study identifies and characterizes CD4+ T cell epitopes specific to Shingrix vaccination, showing a shift in immunodominance from non-structural proteins to gE and mapping HLA restrictions for these epitopes.

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.