Author

A. Umana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 4 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:genome assembly· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. J. Slade· 7 shared B. E. Sanders· 5 shared B. Udayasuryan· 3 shared C. C. Yoo· 3 shared M. A. Casasanta· 3 shared S. S. Verbridge· 3 shared T. T. D. Nguyen· 3 shared B. Wozniak· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersMicrobiology

D. J. Slade

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Type 4 pili mediated natural competence in Fusobacterium nucleatum

B. E. Sanders, A. Umana, T. T. D. Nguyen, K. J. Williams, C. C. Yoo, M. A. Casasanta, B. Wozniak, D. J. Slade

This study characterizes Type 4 pili-mediated natural competence in Fusobacterium nucleatum, showing DNA uptake and chromosomal integration require specific pilus components and DNA methylation.

bioRxiv · Jun 9, 2023 · PreprintMicrobiology

DNA methyltransferase enhanced Fusobacterium nucleatum genetics

A. Umana, T. T. D. Nguyen, B. E. Sanders, K. Williams, B. Wozniak, D. J. Slade

This paper demonstrates using DNA methyltransferases from Fusobacterium nucleatum to bypass restriction-modification systems, enabling efficient genetic modification of previously recalcitrant strains.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

CRISPR-Cas systems in Fusobacterium: An untapped genetic frontier

A. Umana, D. J. Slade

This paper identifies and characterizes CRISPR-Cas systems in Fusobacterium, providing a roadmap for developing genetic tools to study its role in cancer.

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling

B. Udayasuryan, T. T. D. Nguyen, A. Umana, R. A. Ahmad, L. M. Roberts, P. Sobol, S. D. Jones, J. M. Munson, D. J. Slade, S. S. Verbridge

This study shows that Fusobacterium nucleatum in pancreatic cancer promotes cell proliferation and migration through autocrine and paracrine cytokine signaling.

bioRxiv · Nov 19, 2021 · PreprintCancer Biology

Fusobacterium nucleatum host cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

M. A. Casasanta, C. C. Yoo, B. Udayasuryan, B. E. Sanders, A. Umana, Y. Zhang, H. Peng, A. J. Duncan, Y. Wang, L. Li, S. S. Verbridge, D. J. Slade

This study shows that Fusobacterium nucleatum binding and invasion of colorectal cancer cells induces IL-8 and CXCL1 secretion, promoting cancer cell migration and immune signaling.

bioRxiv · Jan 15, 2020Cancer Biology

Reevaluating the Fusobacterium Virulence Factor Landscape

A. Umana, B. E. Sanders, C. C. Yoo, M. A. Casasanta, B. Udayasuryan, S. S. Verbridge, D. J. Slade

The paper redefines the virulence factor landscape of Fusobacterium using complete genomes and experimental validation, showing previously misclassified strains can invade human cells.

bioRxiv · Jan 29, 2019 · PreprintMicrobiology

FusoPortal: An interactive repository of hybrid MinION sequenced Fusobacterium genomes improves gene identification and characterization

B. E. Sanders, A. Umana, J. A. Lemkul, D. J. Slade

FusoPortal provides a repository of hybrid MinION sequenced Fusobacterium genomes, improving gene identification and characterization by correcting misannotations and offering downloadable genomic data.

bioRxiv · Apr 22, 2018Microbiology