K. J. Williams

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

This study shows that PARP14 inhibition restores PD-1 checkpoint inhibitor response in IFNγ-resistant tumors by increasing T cell infiltration and reducing regulatory T cells.

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.

Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses

This study compares molecular mechanisms and antiviral targets of Old and New World hantaviruses using human cell models and identifies potential therapeutic compounds.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Type 4 pili mediated natural competence in Fusobacterium nucleatum

This study characterizes Type 4 pili-mediated natural competence in Fusobacterium nucleatum, showing DNA uptake and chromosomal integration require specific pilus components and DNA methylation.

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

Alveolar macrophage lipid burden correlates with clinical improvement in patients with Pulmonary Alveolar Proteinosis

This study shows that reduced lipid content in alveolar macrophages correlates with clinical improvement in patients with Pulmonary Alveolar Proteinosis.

Invasion and Secondary Site Colonization as a function of In vitro Primary Tumor Matrix Stiffness

This study investigates how breast tissue stiffness affects cancer cell invasion and bone metastasis using in vitro models.

Using generalised dissimilarity modelling and targeted field surveys to gap-fill an ecosystem surveillance network

The paper uses predictive modeling and field surveys to improve ecological coverage in an ecosystem monitoring network by identifying and filling gaps in biodiversity representation.

Stocktaking the environmental coverage of a continental ecosystem observation network

The paper assesses the environmental coverage of the Australian Terrestrial Ecosystem Research Network (TERN) and finds that stratification by bioregions provides better ecological coverage than other sampling methods.

Supporting global biodiversity assessment through high-resolution macroecological modelling: Methodological underpinnings of the BILBI framework

The paper introduces BILBI, a framework for high-resolution macroecological modelling of biodiversity patterns, refining beta-diversity mapping using generalized dissimilarity modelling across global species data.

An oxide transport chain essential for balanced insulin signaling

The paper identifies NSAPP as an oxide transport chain regulated by NADPH oxidase-4 that modulates insulin signaling by inactivating PTEN through H2O2 transport.