Author

M. A. Casasanta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. C. Yoo· 4 shared D. J. Slade· 4 shared A. Umana· 3 shared B. E. Sanders· 3 shared A. J. Duncan· 2 shared B. Udayasuryan· 2 shared S. S. Verbridge· 2 shared A. C. Varano· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

C. C. Yoo

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4 papers

Recent·Most cited

Type 4 pili mediated natural competence in Fusobacterium nucleatum

B. E. Sanders, A. Umana, T. T. D. Nguyen, K. J. Williams, C. C. Yoo, M. A. Casasanta, B. Wozniak, D. J. Slade

This study characterizes Type 4 pili-mediated natural competence in Fusobacterium nucleatum, showing DNA uptake and chromosomal integration require specific pilus components and DNA methylation.

bioRxiv · Jun 9, 2023 · PreprintMicrobiology

Fusobacterium nucleatum host cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

M. A. Casasanta, C. C. Yoo, B. Udayasuryan, B. E. Sanders, A. Umana, Y. Zhang, H. Peng, A. J. Duncan, Y. Wang, L. Li, S. S. Verbridge, D. J. Slade

This study shows that Fusobacterium nucleatum binding and invasion of colorectal cancer cells induces IL-8 and CXCL1 secretion, promoting cancer cell migration and immune signaling.

bioRxiv · Jan 15, 2020Cancer Biology

Reevaluating the Fusobacterium Virulence Factor Landscape

A. Umana, B. E. Sanders, C. C. Yoo, M. A. Casasanta, B. Udayasuryan, S. S. Verbridge, D. J. Slade

The paper redefines the virulence factor landscape of Fusobacterium using complete genomes and experimental validation, showing previously misclassified strains can invade human cells.

bioRxiv · Jan 29, 2019 · PreprintMicrobiology

FplA From Fusobacterium nucleatum Is A Type Vd Autotransporter Phospholipase With A Proposed Role In Altered Host Signaling And Evasion Of Autophagy

M. A. Casasanta, C. C. Yoo, H. B. Smith, A. J. Duncan, K. Cochrane, A. C. Varano, E. Allen-Vercoe, D. J. Slade

This paper characterizes FplA, a Type Vd autotransporter phospholipase from F. nucleatum, showing its potential role in modulating host signaling and evading autophagy.

bioRxiv · May 10, 2017Microbiology